• A candidate protein for the

  2024-03-18

  

  A candidate protein for the regulation of AMPAR transport is CaMKII, a Ca2+-dependent kinase with diverse cellular functions. With respect to synaptic transmission, CaMKII is recognized as a key synaptic protein that is required to modify the number of synaptic AMPARs in response to LTP and LTD stim

• br Conflict of interest statement br Acknowledgement br Intr

  2024-03-18

  

  Conflict of interest statement Acknowledgement Introduction Lipoxygenases (LOs) are enzymes catalyzing the positional as well as stereo-specific introduction of molecular oxygen into 1,4-pentadiene structures found in unsaturated fatty acids such as arachidonic GS967 or linoleic acid [1],

• LOXs and CYPs are a series of iron

  2024-03-18

  

  LOXs and CYPs are a series of iron-containing enzymes that metabolize arachidonic PLX3397 synthesis to form biologically active products, such as epoxyeicosatrienoic acids (EETs) hydroperoxyeicosatetraenoic acids (HETEs), prostaglandins, leukotrienes and thromboxanes [6]. Among these mediators, 12/1

• In large biopsies series from ALK NSCLC treated patients

  2024-03-18

  

  In large biopsies series from ALK+ NSCLC treated patients, the number of detected mutations increased after second generation ALKi (Gainor et al., 2016) and in one study were present in 56% of the entire cohort (Shaw et al., 2013b). For example, the rate of G1202R mutations increases from 2% in post

• In order to get a better understanding of this

  2024-03-18

  

  In order to get a better understanding of this synergy, we tested the effect of preliminary incubation of salidroside with non-stimulating concentrations of gonadotropins or FSK before subsequent stimulation by FSK or gonadotropins alone, also at sub-stimulating concentrations. We observed that hum

• Regenerative mechanisms often require reemployment of pathwa

  2024-03-18

  

  Regenerative mechanisms often require reemployment of pathways used during development in the embryonic and postnatal periods (Waschek, 2002). PACAP has diverse neurodevelopmental and growth factor-like effects (Botia et al., 2007; Vaudry et al., 2009; Waschek, 2002; Watanabe et al., 2016) and it is

• Until now the molecular interactions of Tmod

  2024-03-16

  

  Until now, the molecular interactions of Tmod or Lmod with DMH-1 had been assessed in pyrene-actin polymerization assays [13], [23], [27], [28], [44], [45] or directly measured using non-denaturing polyacrylamide gel-electrophoresis (for Tmod isoforms only [23]), ITC (for Tmod1 and Lmod2) [43], [46]

• Our initial approach to identify hits

  2024-03-16

  

  Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI FPH1 australia library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tolerance for protein flexibility

• br Dihydrotestosterone in adult fish and frogs

  2024-03-16

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• Oxytocin Aurora kinases are a conserved family of serine thr

  2024-03-16

  

  Aurora kinases are a conserved family of serine/threonine kinases that are important for the transition through mitosis and amplification and overexpression of Aurora kinases have been implicated in Oxytocin and transformation. Aurora B is located at the centromere and controls aspects of kinetochor

• Pathological angiogenesis occurs when an imbalance of endoge

  2024-03-16

  

  Pathological angiogenesis occurs when an imbalance of endogenous proangiogenic and antiangiogenic factors occurs. Although the focus of angiogenesis-related drug development has been geared to the discovery of antiangiogenic compounds for use in pathologies where excessive angiogenesis occurs (cance

• br Experimental procedures br Results br Discussion Our biop

  2024-03-16

  

  Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific

• Accumulating evidence indicates that experience

  2024-03-16

  

  Accumulating evidence indicates that experience-dependent alterations in glutamate transmission in the NAc, such as those produced by repeated exposure to cocaine, involve alterations in postsynaptic signaling mediated by AMPA-type receptors (Pierce and Wolf, 2013, Wolf and Ferrario, 2010). In the N

• br Guava tea leaves inhibit leukocyte

  2024-03-16

  

  Guava tea leaves inhibit leukocyte-type 12-lipoxygenase activity Guava tea that is extracted from guava leaves contains a number of polyphenols, and is commonly taken as a dietary supplement. The extracts show a variety of beneficial effects such as antioxidative, anti-inflammatory and antiprolif

• Benztropine mesylate COPD is almost unheard of

  2024-03-15

  

  COPD is almost unheard of in individuals less than 40 years of age (even among heavy smokers), 1 in 10 lifetime never-smokers and 1 in 3 develop COPD by age 75 [26], unquestionably, COPD is an age-related disorder. This notion of accelerated ageing of COPD is supported by animal models, which demons

15964 records 183/1065 page Previous Next First page 上5页 181182183184185 下5页 Last page