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Mice lacking S nitrosoglutathione reductase GSNOR a
2022-04-29
Mice lacking S-nitrosoglutathione reductase (GSNOR), a denitrosylase that regulates S-nitrosylation, have increased levels of S-nitrosoglutathione (GSNO) and exhibit nitrosative stress. GSNO is in equilibrium with protein S-nitrosylation in cells, and GSNOR controls the cellular concentration of pro
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Our results on the association of selenium deficiency and vi
2022-04-26
Our results on the association of selenium deficiency and vitamin A deficiency being associated with greater CD4 recovery during treatment were surprising. As we had hypothesized a relationship in the opposite direction (deficiency being associated with lower CD4 recovery), we can only reflect on po
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cisapride receptor The mD plasmid containing CD
2022-04-26
The mD1.2 plasmid containing CD4 domain 1 gene under the control of a promoter was obtained as a gift from Dr. Dimiter S. Dimitrov. The mD1.2 plasmid was digested using restriction endonuclease I (New England BioLabs, USA) to release the mD1.2 gene. The gene encoding the mD1.2 protein was elongated
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ic propranolol About epilepsy no specific seizure type has
2022-04-25
About epilepsy, no specific seizure type has been identified because GLUT1-DS is associated with a wide range of epilepsies: patients develop seizures in infancy and early childhood, which are, frequently, do not respond to anticonvulsant medication. In infants, seizures are described as brief, subt
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br Regulation of the GLI code by non HH
2022-04-25
Regulation of the GLI code by non-HH signals and by the oncogenic load The GLI code may be seen as the essential parameter to regulate canonical HH output. Its regulation first appeared to be strictly dependent on the presence of specific levels of HH ligands. Indeed, GLI1 transcription is so far
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After initial optimization of the distances
2022-04-25
After initial optimization of the distances we obtained the structure iG shown schematically in Fig. 1. This is the telomeric fragment of chromosome with the noncanonical structures of i-motif and G-quadruplex placed symmetrically in the middle of the duplex. Obviously, we consider the situation whe
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In Kdm c germline and forebrain conditional
2022-04-22
In Kdm5c germline and forebrain conditional knockout mice, RNA sequencing showed the upregulation of a large set of genes, suggesting that Kdm5c functions primarily as a transcriptional repressor [,]. While no changes in global H3K4me3 levels were observed in the knockout neurons, there were thousan
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The components of the SAGA complex
2022-04-22
The components of the SAGA complex including Gcn5 have recently been found to be involved in regulating pathways that are required for development and virulence in different species under the environmental stresses, around 10% of S. cerevisiae genes are activated by the transcriptional coactivator S
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br Discussion The aim of the present study was
2022-04-22
Discussion The aim of the present study was to extend the list of ASIC ligands and to check if histamine receptors ligands can also affect ASICs. The novel finding is that not only histamine but also thioperamide, 1-metylhistamine and Nα-methylhistamine are active ASIC1a potentiators, while other
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Another interesting approach is to use partial
2022-04-22
Another interesting approach is to use partial agonists as starting point to develop specific antagonists like done in earlier decades [64], [65]. Possible indications for an attenuation of the NO/sGC signalling pathway might be specific neuronal disorders: an involvement in the aetiology of migrain
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Beside its role in NF B and IL activation
2022-04-22
Beside its role in NF-κB and IL-1β activation, the NRLP3 pathway is closely involved in another essential pathophysiologic mechanism such as the cellular calcium homeostasis. Full activation of the NRLP3 inflammasome requires decreased extracellular K concentrations resulting in decreased osmotic pr
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Despite the rapid development of synthetic ligands the endog
2022-04-22
Despite the rapid development of synthetic ligands, the endogenous ligands of GPR109A, GPR109B and GPR81 remained elusive until recently. This is probably the result of their relatively low potencies and their metabolite character (Table 1). Traditionally, agonists of GPCRs were believed to belong t
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In the present study we aimed to
2022-04-22
In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA AGK7 australia of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-type vs. lean-type
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Migratory properties of Treg are extremely important for the
2022-04-22
Migratory properties of Treg are extremely important for the potential in vivo application. Therefore, the observed expression of CXCR3 on almost all obtained insulin-specific Treg is crucial for directing Phos-tag into the inflamed tissue (in this case pancreatic islets). CXCR3 responds to CXCL9,
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In the present study administration of
2022-04-22
In the present study, administration of both muscimol and bicuculline also affected the biosynthesis of GnRHR. A significant decrease in GnRHR level in the POA, AH, VMH and SME following muscimol treatment as well as the opposite effect induced by bicuculline indicates that GnRHR gene expression is,
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