• Here we dissect X chromosome dosage

  2021-10-18

  

  Here, we dissect X chromosome dosage compensation (DC) in C. elegans to determine the effect of chromatin modifications on higher-order chromosome structure during long-range gene regulation. DC is exemplary because it controls hundreds of genes simultaneously, it distinguishes X chromosomes from au

• br Conflict of interest br Introduction HAT is

  2021-10-18

  

  Conflict of interest Introduction HAT1 is the founding member of an expanding class of enzymes known as type B histone acetyltransferases (HATs). HATs are divided into two categories, type A and type B [1]. The type A HATs are nuclear enzymes that acetylate histones in the context of rosmarini

• The dramatically reduced expression of

  2021-10-18

  

  The dramatically reduced expression of CFTR in human colorectal cancer tissues identified herein is consistent with our previous findings using human breast cancer tissues, prostate cancer tissues, and colon cancer tissues, and suggests that the loss of CFTR is likely a general phenomenon in epithel

• latest Cysteine Cys residues are frequently found to

  2021-10-18

  

  Cysteine (Cys) residues are frequently found to be highly conserved within functional, regulatory, catalytic, or binding sites of proteins. Thiol or thiolate chemistry imparts active sites with unique properties like nucleophilicity, high affinity metal binding, and disulfide bond assisted multimeri

• br Declaration of interest br Acknowledgments br

  2021-10-18

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

• br FXR Agonists Azepinol b indole hEC nM efficacy eff

  2021-10-18

  

  FXR Agonists Azepinol[4,5-b]indole 1 (hEC50=600nM, efficacy (eff)=100%) was identified as a FXR agonist lead from a high-throughput screening effort. Structure–activity relationship (SAR) studies around the azepine ring demonstrated that dialkyl substitution at C-1 led to a 30-fold improvement in

• The calculations for the R substrate showed that

  2021-10-18

  

  The calculations for the R substrate showed that, like the S substrate, the coordination shell of the Zn D609 is more symmetric than in the HIC-SG crystal structure. This symmetry indicates that the enzyme could use the same reaction mechanisms as for the S substrate, but with exchanged roles of Glu

• Although the overall structures of mGlu and mGlu VFTs

  2021-10-18

  

  Although the overall structures of mGlu2 and mGlu3 VFTs are highly similar, two major differences can be observed: (i) the number of functional Cl− binding sites, one in mGlu2 versus two in mGlu3 receptors and (ii) the loop 7 in lobe 2 is longer in mGlu3 than in the mGlu2 receptor. These two particu

• br STAR Methods br Acknowledgments We would like

  2021-10-18

  

  STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa

• The findings in mice were echoed

  2021-10-18

  

  The findings in mice were echoed in the human studies, in which the effects of higher doses of LY3298178 caused greater weight loss than the selective GLP-1RA dulaglutide. In patients with T2DM, LY3298176 demonstrated meaningful weight loss after only four weeks of treatment. This was consistent wit

• The Growth Hormone Secretagogue Receptor GHSR also known

  2021-10-18

  

  The Growth Hormone Secretagogue Receptor (GHSR), also known as the ghrelin receptor, is a G protein-coupled receptor (GPCR) expressed widely throughout the body and brain, with particular enrichment in Oxybutynin regions concerned with homeostatic and motivational function such as the hypothalamus,

• The identity of the K

  2021-10-18

  

  The identity of the K+ transport pathway activated by NEM remains unclear. The pathway does not require the presence of Gardos channel KCNN4 or K–Cl cotransporters KCC3 and KCC1, but like these pathways is sensitive to the presence of hemoglobin S or other sickling hemoglobins. Although partially se

• The chemical structure of BAs consists of a steroid nucleus

  2021-10-18

  

  The chemical structure of BAs consists of a steroid nucleus with an acidic side chain. They are amphipatic molecules characterized by a hydrophilic α-face and a hydrophobic β-face. The hydrophobic pocket of the FXR LBD interacts with BAs largely through the β-face. The α-face contains several hydrox

• 1-NM-PP1 Brain derived neurotrophic factor BDNF is the

  2021-10-16

  

  Brain-derived neurotrophic factor (BDNF) is the most abundant growth factor in the brain and is critical for neuronal development and synaptic plasticity (Bekinschtein et al., 2008; Lu et al., 2014). Besides playing an important role in mood and cognition, BDNF is also involved in the regulation of

• Receptor activator of NF B ligand RANKL

  2021-10-16

  

  Receptor activator of NF-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) stimulate the generation of osteoclast Bupivacaine HCl mg [10], [11], [12], [13]. In response to sphingosine 1-phosphate (S1P) signaling, osteoclasts then attach to regions of bone undergoing resorption [14]

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