• br Crystal structure of c FMS and

  2021-08-27

  

  Crystal structure of c-FMS and binding pattern of CSF-1 and IL-34 c-FMS is a 972 amino acids polypeptides containing transmembrane glycoprotein [19]. It contains all the necessary domains required for tyrosine kinase activity, i.e. 512 amino Cariprazine N-terminal extracellular segment, hydropho

• Several RNA BPs like the ELAV

  2021-08-27

  

  Several RNA-BPs, like the ELAV protein family member HuR, tristetraprolin (TTP) or the KH-type splicing regulatory protein (KSRP) have been shown to interact with these AREs and thereby lead to stabilization or destabilization of the mRNA [5]. Control of nucleocytoplasmic mRNA export is also very i

• DNA methylation is a relatively stable

  2021-08-27

  

  DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla

• br Author contribution br Acknowledgements QNRF grant number

  2021-08-27

  

  Author contribution Acknowledgements QNRF grant number NPRP6-065-3-012, Qatar National Research Fund, Doha Qatar for funding this work with grant number NPRP No.: NPRP6-065-3-012. Introduction Preeclampsia (PE) affects 3–5 % of pregnancies worldwide and is one of the leading causes of mate

• janex In the case of ionic liquids the association scheme

  2021-08-27

  

  In the case of ionic liquids, the association scheme should be determined and considered for calculations. H. Soltani Panah (2017) suggested the 2B scheme for the imidazolium-based ionic liquids. His speculation has been used in this study for the modeling [22]. Considering 2B association scheme, th

• Kim et al reported for bioactive compounds originating from

  2021-08-27

  

  Kim et al. reported for bioactive compounds originating from the endemic species in Korea, the hexane and EtOAc fractions of the MeOH extracts from the roots of Dystaenia takeshimana (Nakai) Kitagawa (Umbelliferae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity b

• POE specialises Rogers definition of engineering to

  2021-08-27

  

  POE specialises Rogers' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that mitotic inhibitors meets a real-world need N to the satisfaction of a grou

• The recombinant Scl collagen system has

  2021-08-27

  

  The recombinant Scl2 collagen system has shown capability as a biomaterial as well because of its adaptability and scalability. Scl2 was functionalized to crosslink into a hydrogel without disrupting its triple helix [130]. The Scl2–hydrogel crosslinking also did not disrupt cell adhesion and integr

• Salirasib australia Cholesterol homeostasis is maintained th

  2021-08-27

  

  Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The Salirasib australia of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In p

• In our opinion the precise function of

  2021-08-27

  

  In our opinion, the precise function of AE of S. mansoni (Sm32) remains unclear, and accurate knowledge of the three dimensional structure of this enzyme would be valuable for a better understanding the molecular basis of many of its properties, including its role in the host-parasite interaction, a

• We first confirmed LPS induction of markers known to

  2021-08-26

  

  We first confirmed LPS-induction of markers known to induce NF-κB signaling in Caco2BB cells, as established for numerous other cell types [31]. We initially selected this approach to monitor NF-κB activation instead of directly monitoring p65 as it is technically straightforward and provides both u

• P7C3 receptor Dipeptidyl peptidase inhibitors DPP is or

  2021-08-26

  

  Dipeptidyl peptidase-4 inhibitors (DPP-4is or gliptins) stimulate both post-meal insulin secretion and inhibit P7C3 receptor secretion in a glucose-dependent manner, rendering the risk of hypoglycaemia minimal [10]. They are weight-neutral or may even induce slight weight loss. Their good efficacy h

• The data from the Sur lab have showed

  2021-08-26

  

  The data from the Sur lab have showed DNA-PK is involved in metabolic gene regulation in response to insulin. DNA-PK regulates fatty 54011 synthesis by modulating the protein expression of fatty acid synthase (FAS) in a feeding-dependent manner. DNA-PK induces the activation of Upstream Stimulatory

• The thermal behavior of the

  2021-08-26

  

  The thermal behavior of the UV-sensitive nanocomposites was investigated by DSC before and after irradiation in an extended temperature range (from −40 to 250 °C). Fig. 4a shows the thermograms of the non-irradiated GNP-DNA/PDMS nanocomposites in comparison with a neat PDMS sample. The filler-loaded

• br Conclusion br Competing interests br

  2021-08-26

  

  Conclusion Competing interests Authors' contributions Acknowledgements The work was supported by Aurigene Discovery Technologies (M) Sdn. Bhd., Industrial Doctoral Program sponsorship by Ministry of Higher Education, Malaysia and research grants by the University of Malaya, grant number

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