• In the present study we investigated the deeper role of

  2021-05-07

  

  In the present study, we investigated the deeper role of eNOS in the pathogenesis of nasal polyps and analyzed the influence of 1,8-cineol on nasal polyp gene and protein expression of eNOS in vitro. Different studies dealt with the localization and expression of eNOS in nasal polyps and nasal mucos

• Methacholine MCh is a bronchoconstrictive agent that has

  2021-05-07

  

  Methacholine (MCh) is a bronchoconstrictive agent that has been widely used in the diagnoses of airway narrowing and hyperresponsiveness (Jonasson et al., 2009). MCh induces muscle contractions by stimulating the muscarinic cholinergic receptors that are found in both the airways and the lung parenc

• Likewise the conserved cysteine in the E protein

  2021-05-07

  

  Likewise, the conserved cysteine in the E2 protein is the only residue shown to be essential for the transfer of Ub/Ubl from E2 to the HECT ligases (Dye and Schulman, 2007, Wu et al., 2003). However, all other terminal Ub/Ubl transfer reactions involving E2 enzymes suggest a critical role for the ta

• Crystallographic and NMR based analyses have revealed that

  2021-05-07

  

  Crystallographic and NMR-based analyses have revealed that RINGs and U-boxes have a common mode of interaction with E2s (Fig. 2A). The key structural elements are two loop-like regions, which, in the case of RINGs, coordinate Zn. The loops surround a shallow groove formed by the central α-helix. Tog

• Inflammatory action of certain cytokines can influence cell

  2021-05-07

  

  Inflammatory action of certain cytokines can influence cell proliferative routes (Deshmane et al., 2009). When mTOR is inhibited, for instance by the action of Rapa, TGF-β1, which has an anti-inflammatory action, is increased. The relationship between high levels of TGF-β1 and Rizatriptan Benzoate

• Many studies reporting on discoveries of DUBs in

  2021-05-07

  

  Many studies reporting on discoveries of DUBs in the TGFβ and BMP pathways have relied on RNAi strategies to investigate loss-of-function impact. While RNAi strategies are useful tools, there are limitations ranging from limited knockdowns of targets to potential off-target effects. New and better t

• In the past few years we and others have

  2021-05-07

  

  In the past few years we and others have reported that GLP-1 may also be secreted by sub-populations of alpha Fmoc-Glu(OtBu)-OPfp receptor in human pancreatic islets (Marchetti et al., 2012, Ellingsgaard et al., 2011), which could contribute to beta cell function and survival (Marchetti et al., 201

• Addressing whether impaired activation of D and D receptors

  2021-05-07

  

  Addressing whether impaired activation of D1 and D2 receptors regulates memory capacity is relevant for all human pathologies that lead to reduced activation of these NHS-SS-Biotin pathways, such as ageing [39], certain genetic polymorphisms [40] and neurodegenerative disorders. In this study, we h

• To ascertain separation of the distinct enzymatic activities

  2021-05-07

  

  To ascertain separation of the distinct enzymatic activities found in this protein preparation following separation on the HAP column, a rigorous quantitative analysis was conducted on the nickel–agarose elution and HAP FT pools of protein. For these analyses, each pool of protein was dialyzed in th

• Expression of MGMT in human cells can be switched off

  2021-05-07

  

  Expression of MGMT in human NSC 74859 sale can be switched off by enzymatic methylation of a cytosine residue in the MGMT promoter sequence. In this regard, both MGMT and the mismatch repair function MLH1 belong to a subset of DNA repair genes that are subjected to epigenetic control. In consequenc

• br Role of cysLT signaling on

  2021-05-06

  

  Role of cysLT signaling on various neurological complications which are associated with Alzheimer’s disease Alzheimer’s disease, first described in 1906 by Alois Alzheimer, is a neurodegenerative disease and a very common cause of dementia progressively leading to death. Even though years of rese

• br Materials and methods br Results and discussion br Acknow

  2021-05-06

  

  Materials and methods Results and discussion Acknowledgements This study was supported by the Open Project Program of the Key Laboratory of Mariculture & Enhancement of Zhejiang Province (No. 2016KF003), the Key Project of Zhejiang Province (No. 2016C02055-7), and the International Science

• Chemokines act as ligands for the chemokine receptors

  2021-05-06

  

  Chemokines act as ligands for the chemokine receptors, which possess 7-transmembran domain-type proteins functionally coupled to G proteins. Leukocytes express 19 chemokine receptors which control their influx and activation at the site of inflammation. Human neutrophils express both CXCR-1 and CXCR

• Common to all models for nuclear transport is the binding

  2021-05-06

  

  Common to all models for nuclear transport is the binding of importins/exportins to FG repeats found in about a third of the ∼30 nucleoporins, the so-called FG-Nups (Iovine et al., 1995, Rexach and Blobel, 1995); for review, see Grossman et al. (2012), Stewart (2007), and Terry and Wente (2009). FG-

• We and others have previously found that supplementation

  2021-05-06

  

  We and others have previously found that supplementation of old rats with ALCAR remediates the age-related decay in mitochondrial bioenergetics in liver (Hagen et al., 1998a, Hagen et al., 1998b), heart (Paradies et al., 1994, Paradies et al., 1999), muscle (Pesce et al., 2010) and Sodium ascorbate

15883 records 666/1059 page Previous Next First page 上5页 666667668669670 下5页 Last page