• The nucleus accumbens is a critical locus for ER mGluR

  2019-10-07

  

  The nucleus accumbens is a critical locus for ER/mGluR signaling in the context of addiction ER/mGluR signaling is regulated by caveolin proteins and palmitoylation Because of the vast implications of ER/mGluR association, it is important to understand what regulates their interaction. Such regu

• br Conclusion br Conflict of

  2019-10-07

  

  Conclusion Conflict of interest Author contributions Acknowledgements Piyamas Kanokwongnuwut was supported by the Development and Promotion of Science and Technology Talent Project (DPST), Royal Thai Government Scholarship. Funding for the work was provided by the Attorney General’s Depa

• Introduction Collagen deposition is a common

  2019-10-07

  

  Introduction Collagen deposition is a common feature found in cancerous tissues and fibrotic organs/lesions. It is now well accepted that collagen deposition is not just a consequence of disease, but that it can also trigger a vicious cycle. Both chemical and physical signals elicited from collagen

• glucocorticoid receptors Atg cleaves Atg at the peptide

  2019-10-07

  

  Atg4 cleaves Atg8 at the peptide bond on the glycine residue at the C-terminus, thus allowing the conjugation of Atg8 to phosphatidylethanolamine (PE) with the participation of other autophagy molecules. Atg4 can also serve as a deconjugating enzyme, which cleaves the amide bond of the conjugated At

• In this study we reported that over expressed endogenous

  2019-10-07

  

  In this study, we reported that over-expressed endogenous central ET-1 exerted anti-allodynic and anti-hyperalgesic effects on SNL-induced NP for the first time. Furthermore, we showed that ETA-R mRNA Cy5 EGFP together with the level of ET-1 was increased in the CNS up to 21days after SNL surgery in

• We experienced difficulties in observing maturation

  2019-10-07

  

  We experienced difficulties in observing maturation of hESC retinas in rd1 mice even with immunosuppression, but with NOG-rd1-2J mice the transplanted hESC retinas consistently developed mature ONL with rod and cone opsins. Furthermore, graft photoreceptors show signs of developing IS/OS structures

• The data from the Sur lab

  2019-10-05

  

  The data from the Sur lab have showed DNA-PK is involved in metabolic gene regulation in response to insulin. DNA-PK regulates fatty Fmoc-Glu(OtBu)-OPfp and synthesis by modulating the protein expression of fatty acid synthase (FAS) in a feeding-dependent manner. DNA-PK induces the activation of Ups

• Khan et al investigatedAnomalin a pyranocoumarin constituent

  2019-10-05

  

  Khan et al. investigatedAnomalin 44, a pyranocoumarin constituent of S. divaricata, which exhibits potent anti-inflammatory activity. The anomalin 44 dose-dependently inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein expression in LPS-stimulated RAW 264.7

• br Conclusion and future perspectives LDL

  2019-10-05

  

  Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol 1347 and the efficacy of cholesterol lowering, both, with statins and with ezetimibe ex

• At baseline mutant allele frequency of EGFR

  2019-10-04

  

  At baseline, mutant allele frequency of EGFR in tissue and plasma samples did not correlated with anti-tumor response (Supplementary Fig. 1). Among 35 patients who were positive for cell-free DNA (cfDNA) at baseline, changes of cfDNA during treatment were analyzed. Negative conversion (NC) of cfDNA

• br Introduction Natural killer NK

  2019-10-04

  

  Introduction Natural killer (NK) cells have an unique ability to directly lyse transformed, virus-infected or stressed cells without prior sensitization or major histocompatibility complex (MHC) class I restriction [1], [2]. They were initially defined and shown to be important effectors of the i

• On the opposite side sPLA X has

  2019-10-04

  

  On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer amprolium pathway and promotes their survival during nutrient stress. It acts through the products of its

• In the present study we implemented the dendritic RCA induce

  2019-10-03

  

  In the present study, we implemented the dendritic RCA-induced formation of amplifying DNAzyme catalytic labels strategy for sensitive and accurate assay of MTase activity and the detection of DNA methylation. In comparison with the traditional RCA process, the proposed strategy achieved high amplif

• Introduction Collagen fibrillogenesis the assembly of

  2019-10-02

  

  Introduction Collagen fibrillogenesis, the assembly of collagen fibers, is a critical process in the development, maturation, and repair of mammalian tissue. Alterations in the structure and amount of deposited collagen fibers can greatly alter the integrity of the whole tissue. Even a single point

• Contrary to the downregulation of S

  2019-10-02

  

  Contrary to the downregulation of S1PR family GPCRs, CLL cells have increased mRNA expression of the lysophosphatidic (R)-PFI 2 hydrochloride (LPA) family receptors LPAR1, LPAR3 and LPAR4 compared to normal B cells [47]. Increased LPAR1 mRNA has been shown to be associated with more aggressive disea

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